SPAC: A Python Package for Spatial Single-Cell Analysis of Multiplexed Imaging

Jupyter Notebook Submitted 15 April 2025Published 14 January 2026
Review

Editor: @adamltyson (all papers)
Reviewers: @jluethi (all reviews), @kevinyamauchi (all reviews)

Authors

Fang Liu (0000-0002-4283-8325), Rui He (0000-0002-2610-1411), Andrei Bombin (0000-0003-2445-304X), Ahmad B. Abdallah, Omar Eldaghar, Tommy R. Sheeley, Sam E. Ying, George Zaki (0000-0002-2740-3307)

Citation

Liu et al., (2026). SPAC: A Python Package for Spatial Single-Cell Analysis of Multiplexed Imaging. Journal of Open Source Software, 11(117), 8787, https://doi.org/10.21105/joss.08787

@article{Liu2026, doi = {10.21105/joss.08787}, url = {https://doi.org/10.21105/joss.08787}, year = {2026}, publisher = {The Open Journal}, volume = {11}, number = {117}, pages = {8787}, author = {Liu, Fang and He, Rui and Bombin, Andrei and Abdallah, Ahmad B. and Eldaghar, Omar and Sheeley, Tommy R. and Ying, Sam E. and Zaki, George}, title = {SPAC: A Python Package for Spatial Single-Cell Analysis of Multiplexed Imaging}, journal = {Journal of Open Source Software} }
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multiplexed imaging spatial proteomics single-cell analysis tumor microenvironment

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